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By building on the capabilities of our staff and creating a culture that questions and challenges the way we do things, we strive to continuously evolve. Our working culture is open, creative, friendly and collaborative and we welcome applications from dynamic and experienced team members to help us achieve our ambitions and goals.
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4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapies and gene vaccines. The company is setting up a new research and development team at our offices in Cambridge, UK to facilitate the scaling and optimisation of our proprietary DNA manufacturing process.
We are looking for an enthusiastic Finance assistant to assist our CFO and Management Accountant. The role is focused primarily on transactional finance tasks, including accounts payable, accounts receivable, credit control, and bank reconciliations. However, we’re also seeking someone with a keen interest in expanding their skillset and getting involved in more technical aspects of finance, such as analytical reporting. The ideal candidate will be IT-literate, particularly with a solid understanding of Excel, and eager to contribute to various tasks within a small but dynamic team.
Responsibilities:
- Manage the Accounts Payable process. Processing invoices, preparation of payment runs.
- Credit control: assisting with maintaining cash compilation, allocation and reconciliation.
- Daily bank account and credit card reconciliation.
- Analytical reporting on a developing suite of financial and non-financial information
- Assist with the preparation of the Group Annual Report
- Assistance with any other ad hoc duties appropriate to the role
Person Specification:
- Part-qualified UK Financial Accounting Qualification
- Confident IT skills particularly in MS Excel
- Ideally comfortable working in a small but dynamic team
- Keen to advance and learn new things
- Comfortable being involved in technical as well as transactional aspects
- Must hold right to work in the UK
What we can offer:Competitive salary + private healthcare + pension contributions + life assurance
If you are interested in joining the 4basebio team, please forward your CV to HR@4basebio.com
4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapies and vaccine platforms. We are expanding our research and development team at our site just North of Cambridge, UK to facilitate GMP production of our DNA products for use in mRNA and viral applications, as well as developing non-viral nanoparticles for nucleic acid delivery.
We are looking for a curious, enthusiastic scientist to join our template generation team. The role will focus on the development and optimisation of techniques used in process development involved in synthetic DNA synthesis. We seek a motivated and organised scientist with experience in molecular biology techniques, eager to learn new skills in a dynamic, innovative, and collaborative environment.
Responsibilities:
- Working as a part of the template generation team and Molecular biology, the successful candidate will be trained in to deliver projects to a high standard and will use cutting edge techniques, including experimental design, synthetic biology.
- Plan and execute experiments, including assessing problems and troubleshooting to ensure successful project delivery in a timely fashion
- Work collaboratively and support the R&D functions of the Company
- Attend and participate in relevant meetings, training, and development sessions
- Undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested
- Keep up to date with relevant scientific and technical developments
- Establish and maintain a detailed record of all the experiments and results generated in the lab
Person Specification:
- BSc or MSc in biochemistry, molecular biology, or related life science field
- Hands-on experience working in biology or chemistry labs
- Experience with lab techniques such as gel electrophoresis, PCR and DNA quantification.
- Experience working with E. coli and plasmid preps is desirable
- Experience with DNA assembly techniques is desirable
- Ability to test and troubleshoot assays and techniques
- Excellent team working and communication skills
- Excellent organizational skills with a keen attention to detail
- Ability to analyse samples using scientific instruments and follow safety rules
- Clean and maintain equipment’s
- Collect, Interpret, present experimental data
- Must hold the right to work in the UK
What we can offer:
Competitive salary + private healthcare + pension contributions + life assurance
If you are interested in joining the 4basebio team, please forward your CV to HR@4basebio.com
Due to the high number of applicants, if you do not hear back from us within six weeks, we thank you for your interest, but please assume you have not been selected for interview on this occasion.
4basebio is an innovation driven biotechnology company enabling and accelerating development of advanced therapy medicinal products through its high performant synthetic DNA products and non-viral, thermostable nucleic acid delivery platform.
Job purpose:
To help operate our Quality Management System (QMS), in compliance with current Good Manufacturing Practices (cGMP). This administrative and operational position will play an active role in all key QMS activities and support users throughout the business to ensure procedural compliance.
Responsibilities:
- Contribute to the implementation and management of a cGMP-compliance Quality management System (to include internal auditing/self-inspections, stability programs, process validation and tech transfer, change control, deviations, investigations, corrective actions and risk management, document management, training record coordination, supplier management)
- Support audits by customers and regulatory bodies
- Deliver group and individual training on QMS and cGMP topics
- Maintain QMS documentation, keep accurate records and comply with company policies in accordance with cGMP regulations
- Advocate the importance of Quality and compliance, and foster healthy collaborations with the Production and Quality Control Teams
Person Specification:
- Educated to degree level, with relevant industry experience
- Demonstrable understanding and application of relevant cGMP Quality Management Systems
- Scrupulous attention to detail and investigative thinking
- Comfortable working autonomously or collaboratively
- Methodical, organised, and able to prioritise work effectively
If you are interested in joining the 4basebio team, please forward your CV to HR@4basebio.com
Due to the high number of applicants, if you do not hear back from us within six weeks, we thank you for your interest, but please assume you have not been selected for interview on this occasion.
4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapy and gene editing platforms. We are expanding our DNA purification Team at our site in Cambridge, UK and are looking for dynamic and experienced team members to help us achieve our ambitions and goals.
The role will focus on the support of Purification and analytics department dedicated to developing the downstream processing of our novel, synthetic DNA products for customer projects. In addition, there will be opportunity for the candidate to expand their laboratory skill set and to interact with a multidisciplinary R&D team.
Key Responsibilities:
- Work as part of the Purification Team for the purification and analysis of synthetic DNA.
- Prepare buffers and related solutions for onsite processors.
- Set up and maintain purification systems such AKTAs and TFF system.
- Set up and maintain analytics systems such HPLC.
- Prepare samples for analytics.
- Assist to maintain the cleanliness of work area.
- Check inventory and replenish consumables supplies.
- Analyse and interpret experimental data; identify and solve experimental problems.
- Use and maintain company equipment in accordance with the company’s SOPs and health & safety guidelines.
- Establish and maintain a detailed record of all the experiments and results generated in the lab.
- Attend and participate in relevant meetings, training, and development sessions.
Person Specification:
- BSc in biochemistry, molecular biology, or related life science field, alternatively a candidate with relevant experience, at least 2 years.
- Ability to manage own load, work under pressure and to multiple deadlines.
- Excellent interpersonal skills, verbal and written.
- Good analytical approach and problem solving.
- Hands-on experience working in biology or chemistry labs.
- Experience in analytical techniques such agarose gels, nucleic acids quantification techniques, SDS-PAGE gels, silver staining and western blotting.
- Expertise in purification with AKTA systems (desired)
- Experience in TFF system operation (desired)
- Ability to test and troubleshoot new assays and techniques.
- Excellent team working and communication skills.
What we offer:
Competitive salary + comprehensive benefits package
If you are interested in joining the 4basebio team, please forward your CV to HR@4basebio.com
Due to the high number of applicants, if you do not hear back from us within six weeks, we thank you for your interest, but please assume you have not been selected for interview on this occasion.
4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapy and vaccine platforms. We are expanding our teams at our premises just North of Cambridge, UK, to continue supporting the GMP production of our DNA products for use as a starting material in mRNA and viral vector production as well as an API for use in drug products.
We are growing our process development and technology transfer teams, supporting scale-up/scale-down studies, process change validation and troubleshooting. The role will involve performing downstream process development experiments to demonstrate that the process is robust, scalable, and able to be performed in the manufacturing facility – as well as the accompanying documentation. The successful candidate will be familiar with cGMP and GDP, and you will support training and documentation during process transfer to Manufacturing.
This position requires great attention to detail, ability to work in a team environment and a keen interest in optimisation of processes. Scientists will be responsible for adhering to all Quality Management System procedures, safety policies, and relevant parts of cGMP.
Responsibilities:
- Perform as a key member of the Downstream Process Development team, liaising with R&D and manufacturing departments.
- Perform process development operations, including but not limited to Development, optimisation and scale-up of downstream chromatography processes. As well as other downstream unit operations
- Stay up to date with current technologies and literature as well as evaluating these new technologies/processes for implementation.
- Contribute to continuous improvement projects on current/future downstream process operations.
- Assist with tech transfer activities from the Process development group in R&D to the cGMP manufacturing facility.
- Generate documentation, such as reports/experimental write-ups, that support the validation of processes.
- Execute and deliver projects to a high standard and in accordance with project validation plans.
- Work collaboratively to support the R&D and manufacturing functions of the Company.
- Record experimental methods and results to a high standard and in-line with company guidelines, maintaining QMS documentation as necessary.
- Attend and participate in relevant meetings, training, and development sessions.
- Use, maintain and respect company equipment in accordance with the company’s SOPs and health & safety guidelines.
- Undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested.
Person Specification:
- MSc in Biochemical engineering (or similar) or BSc in biological sciences, or a related discipline with relevant industry experience (2+ Years). Alternatively, a bioscience apprenticeship with relevant experience.
- Experience of working in controlled environments employing quality standards (e.g., ISO, cGMP, cGLP, cGCP)
- Experience with Chromatographic process development using AKTA systems.
- Experience with scale up and/or tech transfer of chromatographic processes would be desirable.
- Experience with TFF systems.
- Experience of experimental planning, experimental validation and report writing is desirable.
- Experience in analysis of chromatographic data and understanding the implications of certain product impurities.
- DoE experience using software packages such as JMP would be desirable but not essential.
- A creative and open mindset to tackle novel challenges.
- Excellent team working and communication skills.
- Excellent record keeping skills.
If you are interested in joining the 4basebio team, please forward your CV to HR@4basebio.com
Due to the high number of applicants, if you do not hear back from us within six weeks, we thank you for your interest, but please assume you have not been selected for interview on this occasion.
For more information and how our technologies can help you, please contact us
